SKF-34288 hydrochloride is an inhibitor of phosphoenolpyruvate carboxykinase (PEPCK),and inhibits Asn metabolism and results in an increase in amino acids and amides.

2-Amino-6-cyclopropylamino-9H-purine,the key intermediate of abacavir was synthesized from ethyl cyanoacetate by nitrosation,cyclization with guanidine hydrochloride in the presence of EtONa and reduction to give 2,4,5-triamino-6-hydroxypyrimidine.

AA41612 is a novel antagonist of melanopsin-mediated phototransduction.